Urticaria: recommendations from the Italian Society of Allergology, Asthma and Clinical Immunology and the Italian Society of Allergological, Occupational and Environmental Dermatology.

Urticaria is a disorder affecting skin and mucosal tissues characterized by the occurrence of wheals, angioedema or both, the latter defining the urticaria-angioedema syndrome.

It is estimated that 12-22% of the general population has suffered at least one subtype of urticaria during life, but only a small percentage (estimated at 7.6-16%) has acute urticaria, because it is usually self-limited and resolves spontaneously without requiring medical attention.

This makes likely that its incidence is underestimated. The epidemiological data currently available on chronic urticaria in many cases are deeply discordant and not univocal, but a recent Italian study, based on the consultation of a national registry, reports a prevalence of chronic spontaneous urticaria of 0.02% to 0.4% and an incidence of 0.1-1.5 cases/1000 inhabitants/year.

We reviewed the recent international guidelines about urticaria and we described a methodologic approach based on classification, pathophysiology, impact on quality of life, diagnosis and prognosis, differential diagnosis and management of all the types of urticaria.

hInsulin FRET 50

IH1017-50 1 Kit
EUR 266

hInsulin TRF 50

IHTR1017-50 1 Kit
EUR 288

hCRP FRET 50

CH1021-50 1 Kit
EUR 266

hCRP TRF 50

CHTR1021-50 1 Kit
EUR 288

KinaSorb™ 50

KE785-50 50 preps
EUR 1567

mIgG TRF 50

MIGTR1020-50 1 Kit
EUR 288

rIgG FRET 50

RI1024-50 1 Kit
EUR 266

TruStrip Sample Transfer Strips, 50-ul, 50/Pk (without sample tracking dye)

STS-50-50 1 Pk Ask for price

TruStrip Sample Transfer Strips, 50-ul, 50/Pk (with sample tracking dye)

STSD-50-50 1 Pk Ask for price

MTBK_20640-50

AR02-P0011-50 50ug
EUR 727

Bridge-It L-Tryptophan 50

1-1-1001A 1 Kit
EUR 266

Bridge-It L-MET 50

1-1-1005A 1 Kit
EUR 266

Rabies(Rab-50) Antibody

BNUM0943-50 50uL
EUR 395
Description: Primary antibody against Rabies(Rab-50), 1mg/mL

FUNNEL, 50 MM, PP

6120P-50 24/pk
EUR 49
Description: Reusable Plastics; Reusable Funnels

Adrenomedullin (ADM/AM, 1-50), rat

SP-100046-1 1 mg
EUR 529

Rv0351 (GrpE)-50

AR02-P0003-50 50ug
EUR 173

Rv1009 (RpfB)-50

AR02-P0006-50 50ug
EUR 727

Rv2450c (RpfE)-50

AR02-P0007-50 50ug
EUR 727

Rv3875 (esxA)-50

AR02-P0008-50 50ug
EUR 727

Rv2031c(HspX)-50

AR02-P0009-50 50ug
EUR 727

Rv3131 (NfnB)-50

AR02-P0010-50 50ug
EUR 727

ERLENMEYER FLASK, 50 ML, PP

4985P-50 6/pk
EUR 50
Description: Reusable Plastics; Reusable Erl Flasks

ERLENMEYER FLASK, 50 ML, PMP

4990P-50 6/pk
EUR 54
Description: Reusable Plastics; Reusable Erl Flasks

Rv2769c (PE27 protein)-50

AR02-P0001-50 50ug
EUR 295

TR-FRET Bridge-It SAM 50

TRF-1-1-1003A 1 Kit
EUR 288

slingshot homolog 1 (SSH1)(MBP-his tagged)-50

AR09-P0023-50 50ug
EUR 4597

Cytokeratin 5/8(C-50) Antibody

BNUM0948-50 50uL
EUR 395
Description: Primary antibody against Cytokeratin 5/8(C-50), 1mg/mL

DNA Gel Extraction Kit - 50 Columns

31030-50 1kit
EUR 155
Description: Minimum order quantity: 1 unit of 1kit

Super piggyBac Transposase expression vector (replaces PB200A-1), 50 rxns

PB210PA-1 10 ug
EUR 508
  • Category: PiggyBac Technology

RNAfection, RNA transfection reagent 50 ul

MR750A-1 50 ul
EUR 210
  • Category: Stem Cell Products

TR-FRET Bridge-It L-Tryptophan 50

TRF-1-1-1001A 1 Kit
EUR 288

TR-FRET Bridge-It L-MET 50

TRF-1-1-1005A 1 Kit
EUR 288

DiagNano Fluorophore Labeled Gold Nanoparticles, 50 nm

GFL-50 1 mL
EUR 1053

MTBK 20620 (PE protein)-50

AR02-P0005-50 50ug
EUR 830

Aflatoxin G2

A118-0.5MG 0.5 mg
EUR 157

Aflatoxin G2

A118-2.5MG 2.5 mg
EUR 473

M-phase inducer phosphatase 1 (CDC25A)(MBP-his tagged)-50

AR09-P0030-50 50ug
EUR 698

TruStrip Sample Storage/Transportation Trays (5 trays/cluster; 10 clusters for 50 strips) for 15-50 ul strips

STT5-50 1 Pk Ask for price

DiagNano Gold Nanoparticle Passive Conjugation Kit, 50 nm

GPK-50 1 kit
EUR 715

Rv0350 (Heat Shock Protein 70)-50

AR02-P0002-50 50ug
EUR 180

Rv2299c (Heat Shock Protein 90)-50

AR02-P0004-50 50ug
EUR 222

Excision only piggyBac Transposase expression vector, 50 rxns

PB220PA-1 10 ug
EUR 508
  • Category: PiggyBac Technology

protein tyrosine phosphatase, non-receptor type 1 (PTPN1)(His tagged)-50

AR09-P0027-50 50ug
EUR 141

Antigen Retrieval Solution, Citrate pH 6.0 (50 ml, 100X)

ARS6-50 5 L
EUR 286

Antigen Retrieval Solution, EDTA pH 8.0 (50 ml, 100X)

ARS8-50 5 L
EUR 286

Single channel mini-pipette (130 mm) 50 ul, autoclavable

SCMP-50 1
EUR 92

PTPRF(His tagged) / LAR(His tagged)-50

AR09-P0002-50 50ug
EUR 431

ExoQuick-CG cGMP-grade Exosome Isolation reagent (50 ml)

EXOCG50A-1 50 ml
EUR 1181
  • Category: Exosomes

Adrenomedullin (1-50), rat

HY-P1534 1mg
EUR 452

Adrenomedullin (1-50), rat

5-00619 4 x 1mg Ask for price

Antigen Retrieval Solution, Tris-EDTA pH 9.0 (50 ml, 100X)

ARS9-50 5 L
EUR 286

BasicExoRNA? Basic RNA extraction kit (Pre-isolated exosomes, 50 reactions)

K1222-50
EUR 1219

PLGA poly(lactic-co-glycolic) acid); synthetic; (50% lactic and 50% glycolic acid, ~30-60 Kda)

AV-2010-1 0.1 g
EUR 189

Adrenomedullin (Adrenomedullin (ADM/AM, 11-50) (rat)

SP-100047-1 1 mg
EUR 529

slingshot homolog 3 (SSH3)(MBP-his tagged)-50

AR09-P0024-50 50ug
EUR 696

AXYPREP MAG DYECLEAN KIT- 50 ML - 5000 PREPS

MAG-DYECL-50 1/pk
EUR 1068
Description: Bioscience Mag Beads; Magnetic Dye

RESERVOIR, POLYPROPYLENE, 50 ML, V-BOTTOM, NONSTERILE, BULK

RES-V-50 100/pk
EUR 67
Description: Reservoirs; Reservoirs - Axygen

Human IgG/RF-adsorbent (Adsorb 50 serum samples of 100 ul)

RFAD11-50 50 tests
EUR 164

PTPRC(His tagged) / Human CD45 (LCA)(His tagged)-50

AR09-P0001-50 50ug
EUR 219

PTPN5(MBP-his tagged) / STEP(MBP-his tagged)-50

AR09-P0003-50 50ug
EUR 160

PTPN11(MBP-his tagged) / SHP2(MBP-his tagged)-50

AR09-P0004-50 50ug
EUR 447

ACP1(MBP-his tagged) / LMPTP(MBP-his tagged)-50

AR09-P0005-50 50ug
EUR 219

DUSP3(MBP-his tagged) / VHR(MBP-his tagged)-50

AR09-P0006-50 50ug
EUR 195

DUSP14(MBP-his tagged) / MKP6(MBP-his tagged)-50

AR09-P0007-50 50ug
EUR 160

dual specificity phosphatase 12 (DUSP12)(MBP-his tagged)-50

AR09-P0017-50 50ug
EUR 698

DiagNano Fluorophore Labeled Gold Nanoparticles, 50 nm, Cellular Uptake

GFL-50-CU 1mL
EUR 1365

DiagNano Gold Nanoparticle Medium Covalent Conjugation Kit, 50 nm

GCK-M-50 1 kit
EUR 757

Pyrene azide 1, 50 mg

E1530 50 mg
EUR 501

TGF a (1-50) (rat)

H-5545.0050 50.0µg
EUR 1118
Description: Sum Formula: C244H361N71O71S6; CAS# [89899-53-6] net

TGF a (1-50) (rat)

H-5545.1000 1.0mg
EUR 16352
Description: Sum Formula: C244H361N71O71S6; CAS# [89899-53-6] net

HIV-1 Rev (34-50)

HY-P1586 5mg
EUR 681

1-Ethynyl pyrene, 50 mg

515B0 50 mg
EUR 52

Human IgG-RF stripper/Adsorbent (1 ml, sufficient for stripping 50 samples of 100 ul human serum/plasma)

RFS-1 1 ml
EUR 103

Cold Fusion Cloning Kit with Competent Cells (50 rxns) International Sales Only

MC101A-1 50 reactions
EUR 1129
  • Category: Molecular Tools

Phosphate Buffered Saline powder (PBS) pH 7.4, 50 l

12-9425-1 50 l
EUR 115

PLGA(50:50)(8K)-PEG-Mal

abx085344-05kDa500mg 0.5 kDa; 500 mg
EUR 1080
  • Shipped within 5-10 working days.

PLGA(50:50)(8K)-PEG-Mal

abx085344-1kDa500mg 1 kDa; 500 mg
EUR 1205
  • Shipped within 5-10 working days.

PLGA(50:50)(8K)-PEG-Mal

abx085344-2kDa500mg 2 kDa; 500 mg
EUR 1233
  • Shipped within 5-10 working days.

PLGA(50:50)(8K)-PEG-Mal

abx085344-34kDa500mg 3.4 kDa; 500 mg
EUR 1233
  • Shipped within 5-10 working days.

Lanosterol, 50%

GP3911-1G 1 g
EUR 52

AXYPREP FRAGMENTSELECT-I KIT- 50 ML - 380 PREPS

MAG-FRAG-I-50 1/pk
EUR 659
Description: Bioscience Mag Beads; Magnetic Fragment Select

RESERVOIR, POLYPROPYLENE, 50 ML, V-BOTTOM, STERILE, BULK

RES-V-50-S 5/pk
EUR 112
Description: Reservoirs; Reservoirs - Axygen

PTP4A3(MBP-his tagged) / PRL-3(MBP-his tagged)-50

AR09-P0008-50 50ug
EUR 144

dual specificity phosphatase-like 15 (DUSP15)(MBP-his tagged)-50

AR09-P0018-50 50ug
EUR 1154

dual specificity phosphatase-like 18 (DUSP18)(MBP-his tagged)-50

AR09-P0019-50 50ug
EUR 1154

hSKRP1 mRNA for SKRP1 (NE1, DUSP19)(MBP-his tagged)-50

AR09-P0020-50 50ug
EUR 1154

dual specificity phosphatase-like 21 (DUSP21)(MBP-his tagged)-50

AR09-P0021-50 50ug
EUR 348

dual specificity phosphatase-like 26 (DUSP26)(MBP-his tagged)-50

AR09-P0022-50 50ug
EUR 1154

protein tyrosine phosphatase zeta-polypeptide (PTPRZ)(MBP-his tagged)-50

AR09-P0025-50 50ug
EUR 2080

M-phase inducer phosphatase 3 (CDC25C)(MBP-his tagged)-50

AR09-P0031-50 50ug
EUR 1154

DiagNano Gold Nanorods, diameter 50 nm, absorption max 600 nm

BR-50-600 25 mL
EUR 720

DiagNano Gold Nanorods, diameter 50 nm, absorption max 700 nm

BR-50-700 25 mL
EUR 720

DiagNano Gold Nanorods, diameter 50 nm, absorption max 800 nm

BR-50-800 25 mL
EUR 720

SureSeal S Sterile Microtube, 1.5mL, packed in self-standing bags of 50, 10 bags/pk

C2000-50 500/pack
EUR 63.16
Description: Micro Centrifuge Tubes

100 bp DNA Ladder Plus, ready-to-use, 50 ug, 0.5 ug per lane

Z6030001-1 100 lanes
EUR 109

TruStrip RDT Chicken Serum Albumin (CSA) Rapid Test Cards, 50/pk

ALB15-RDT-50 1 Pk
EUR 537

protein tyrosine phosphatase, receptor type, N (PTPRN)(MBP-his tagged)-50

AR09-P0010-50 50ug
EUR 698

protein tyrosine phosphatase, receptor type, O (PTPRO)(MBP-his tagged)-50

AR09-P0012-50 50ug
EUR 1154

protein tyrosine phosphatase, receptor type, S (PTPRS)(MBP-his tagged)-50

AR09-P0014-50 50ug
EUR 815

50 L RPMI 1640, POWDER WITH L-GLUTAMINE, WITHOUT SODIUM BICARBONATE

50-020-PC 50 L/pk
EUR 92
Description: Media Catalog; Classical Media

DiagNano Organic Gold Nanorods, diameter 50 nm, absorption max 700 nm

OR-50-700 1mL
EUR 1022

DiagNano Amine Gold Nanorods, diameter 50 nm, absorption max 700 nm

RFA-50-700 1 mL
EUR 1022

DiagNano Carboxyl Gold Nanorods, diameter 50 nm, absorption max 700 nm

RFC-50-700 1 mL
EUR 1022

DiagNano Methyl Gold Nanorods, diameter 50 nm, absorption max 700 nm

RFM-50-700 1 mL
EUR 1022

DiagNano NHS Gold Nanorods, diameter 50 nm, absorption max 700 nm

RFN-50-700 1 mL
EUR 1022

PLGA(50:50)?8K?-PEG-Mal,1K

HE086022-1K-500mg 500mg
EUR 667
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

PLGA(50:50)?8K?-PEG-Mal,2K

HE086022-2K-500mg 500mg
EUR 642
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

PLGA(50:50)?8K?-PEG-Mal,3.4K

HE086022-3.4K-500mg 500mg
EUR 642
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

PLGA(50:50)?8K?-PEG-Mal,500

HE086022-500-500mg 500mg
EUR 765
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

PLGA(50:50)?8K?-PEG-Mal,5K

HE086022-5K-500mg 500mg
EUR 642
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

AXYPREP MAG PCR NORMALIZER KIT- 50 ML - 384 PREPS

MAG-PCR-NM-50 1/pk
EUR 623
Description: Bioscience Mag Beads; Magnetic PCR Normaliser

RESERVOIR, POLYPROPYLENE, 50 ML, V-BOTTOM, STERILE, INDIVIDUALLY PACKAGED

RES-V-50-SI 100/pk
EUR 139
Description: Reservoirs; Reservoirs - Axygen

comb 1 mm thick 50 sample

EHS1400-C50-1.0 ea
EUR 56

HIV-1 rev Protein (34-50)

H-3026.0500 0.5mg
EUR 334
Description: Sum Formula: C97H173N51O24; CAS# [141237-50-5]

HIV-1 rev Protein (34-50)

H-3026.1000 1.0mg
EUR 576
Description: Sum Formula: C97H173N51O24; CAS# [141237-50-5]

HIV-1 rev Protein (34-50)

5-01319 4 x 1mg Ask for price

1 mm, 50 m Silicone Tube

1292301 1unit
EUR 354
Description: 1 mm I .D. - 3 mm O.D.

Human Exosome lysate positive protein control (10ug/ul), Size 50 ul

EXOAB-POS-1 500 ug
EUR 356
  • Category: Exosomes

AXYGEN® AXYPET® PRO 5-50 ΜL SINGLE-CHANNEL PIPETTOR, AUTOCLAVABLE

AP-50-P 1/pk
EUR 202
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

protein tyrosine phosphatase, non-receptor type 2 (PTPN2)(MBP-his tagged)-50

AR09-P0009-50 50ug
EUR 698

protein tyrosine phosphatase receptor type R gene (PTPRR)(MBP-his tagged)-50

AR09-P0013-50 50ug
EUR 1154

protein tyrosine phosphatase, non-receptor type 7 (PTPN7)(MBP-his tagged)-50

AR09-P0015-50 50ug
EUR 1154

protein tyrosine phosphatase, non-receptor type 12 (PTPN12)(MBP-his tagged)-50

AR09-P0016-50 50ug
EUR 512

DiagNano Fluorophore Labeled Gold Nanorods, diameter 50 nm, absorption max 700 nm

RFL-50-700 1 mL
EUR 1022

DiagNano GSH conjugated Gold Nanorods, diameter 50 nm, absorption max 700 nm

RGS-50-700 1 mL
EUR 1022

DiagNano NeutrAvidin conjugated Gold Nanorods, diameter 50 nm, absorption max 700 nm

RCN-50-700 1 mL
EUR 1022

DiagNano Streptavidin conjugated Gold Nanorods, diameter 50 nm, absorption max 700 nm

RCS-50-700 1 mL
EUR 1022

TruStrip Sample Transfer Strips, 5-ul, 50/Pk (without sample tracking dye)

STS-05-50 1 Pk Ask for price

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TruStrip Sample Transfer Strips, 25-ul, 50/Pk (without sample tracking dye)

STS-25-50 1 Pk Ask for price

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STSD-05-50 1 Pk Ask for price

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AXYPREP MAG PCR CLEAN UP KIT- 50 ML - 1110 PREPS

MAG-PCR-CL-50 1/pk
EUR 579
Description: Bioscience Mag Beads; Magnetic PCR Clean Up

TruStrip Sample Storage/Transportation Trays (5 trays/cluster; 10 clusters for 50 strips) for 200-800 ul strips

STT10-50 1 Pk Ask for price

Acid Green 50

GT1171-100G 100 g
EUR 86

Acid Green 50

GT1171-25G 25 g
EUR 46

Acid Green 50

GT1171-500G 500 g
EUR 229

Sephadex G-50

abx082119-25g 25 g
EUR 342
  • Shipped within 5-10 working days.

CstF-50 Antibody

20-abx007538
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

CA 50 antibody

10-C51A 1 mg
EUR 916
Description: Mouse monoclonal CA 50 antibody

CA 50 protein

30-1068 50 kU
EUR 2996
Description: Purified native Human CA 50 protein

CA 50 protein

30-CA50A 25 KU
EUR 457
Description: Partially purified CA 50 protein from cell culture concentrate

Sepadextran-50 Fine

SD50F-100 100 g
EUR 311

Sepadextran-50 Fine

SD50F-500 500 g
EUR 1191

Sepadextran-50 Medium

SD50M-100 100 g
EUR 344

Sepadextran-50 Medium

SD50M-500 500 g
EUR 1285

Sepadextran-50 Superfine

SD50SF-100 100 g
EUR 377

pQE- 50 Plasmid

PVT0528 2 ug
EUR 325

Glutaraldehyde, 50% solution

G0875 25ml
EUR 60.44
  • Product category: Biochemicals/Biology Reagents/Other

EZ-LINE Reservoir, 50 ml, 1 channel, indiv wrapped, sterile, 50 per case

SP33161 1CS, 50UNIT
EUR 95.59
  • Product category: Labware/Reagent Reservoirs/Single-Channel

protein tyrosine phosphatase, receptor type, N polypeptide 2 (PTPRN2) (MBP-his tagged)-50

AR09-P0011-50 50ug
EUR 1154

Protein tyrosine phosphatase type IVA 2 , member 2 (PTP4A2)(MBP-his tagged)-50

AR09-P0029-50 50ug
EUR 422

DiagNano Protein A conjugated Gold Nanorods, diameter 50 nm, absorption max 700 nm

RCA-50-700 1 mL
EUR 1022

DiagNano Gold Nanorods Covalent Conjugation Kit, diameter 50 nm, absorption max 700 nm

RCK-50-700 1 kit
EUR 1043

TruStrip WBV NS1 Flaviviruses (Zika, WNV, DENV, YFV) Explorer Western Blot Validation Strips (50/pk); Ab Type: Human IgG

WBFEX1100-50 1 Pk
EUR 1260

TruStrip WBV NS1 Flaviviruses (Zika, WNV, DENV, YFV) Explorer Western Blot Validation Strips (50/pk); Ab Type: Human IgM

WBFEX1105-50 1 Pk
EUR 1260

TruStrip WBV Env Flaviviruses (Zika, WNV, DENV, YFV) Explorer Western Blot Validation Strips (50/pk); Ab Type: Human IgG

WBFEX1200-50 1 Pk
EUR 1260

TruStrip WBV Env Flaviviruses (Zika, WNV, DENV, YFV) Explorer Western Blot Validation Strips (50/pk); Ab Type: Human IgM

WBFEX1205-50 1 Pk
EUR 1260

TruStrip WBV prM Flaviviruses (Zika, WNV, DENV, YFV) Explorer Western Blot Validation Strips (50/pk); Ab Type: Human IgG

WBFEX1300-50 1 Pk
EUR 1260

TruStrip WBV prM Flaviviruses (Zika, WNV, DENV, YFV) Explorer Western Blot Validation Strips (50/pk); Ab Type: Human IgM

WBFEX1305-50 1 Pk
EUR 1260

TruStrip WBV MERS Proteins (NP, S1, S2, RBD) Explorer Western Blot Validation Strips (50/pk); Ab Type: Human IgG

WBMEX2100-50 1 Pk
EUR 1260

TruStrip WBV MERS Proteins (NP, S1, S2, RBD) Explorer Western Blot Validation Strips (50/pk); Ab Type: Human IgM

WBMEX2105-50 1 Pk
EUR 1260

TruStrip WBV MERS Proteins (NP, S1, S2, RBD) Explorer Western Blot Validation Strips (50/pk); Ab Type: Mouse IgG

WBMEX2110-50 1 Pk
EUR 1260

TruStrip WBV MERS Proteins (NP, S1, S2, RBD) Explorer Western Blot Validation Strips (50/pk); Ab Type: Camel IgG

WBMEX2120-50 1 Pk
EUR 1260

TruStrip WBV MERS Proteins (NP, S1, S2, RBD) Explorer Western Blot Validation Strips (50/pk); Ab Type: Bat IgG

WBMEX2130-50 1 Pk
EUR 1260

calibration solution 50 ml 1 m kcl

B062 ea
EUR 21

VENT CAP,43MM,S,IND,1/50

431372 1/pk
EUR 194
Description: Erlenmeyer Flasks; Corning Erlenmeyer Flasks

The aim of the present document from the Italian Society of Allergology, Asthma and Clinical Immunology (SIAAIC) and the Italian Society of Allergological, Occupational and Environmental Dermatology (SIDAPA) is to provide updated information to all physicians involved in diagnosis and management of urticaria and angioedema.